case report

Oman Medical Journal [2018], Vol. 33, No. 6: 523-526  

Lemierre’s Syndrome

Suad Marhoon Al Duwaiki1*, Aliya Sarhan Al Barwani2 and Sawsan Taif2

1Radiology Department, Sultan Qaboos University Hopital, Muscat, Oman

2Radiology Department, Khoula Hospital, Muscat, Oman

article info


Lemierre’s syndrome is a rare, life-threatening condition, which may be fatal if not properly treated. This disease refers to thrombophlebitis of the internal jugular vein, which is the result of bacterial sore throat infection (usually in the form of pharyngitis) that extends into the parapharyngeal space. However, it can result from other infective foci in the ear, nose, parotid glands, and paranasal sinuses. The bacteria typically responsible is Fusobacterium necrophorum. Here, we describe a case of Lemierre’s syndrome that occurred in a 20-year-old female who presented with neurological deficits following a two-week history of upper respiratory tract infection. Our case displayed typical findings of this rare condition with a review of the previous literature and also to emphasize the importance of high index of suspicion to reduce the mortality of this disease.

Lemierre’s syndrome is a rare, life-threatening condition, which may be fatal if not properly treated. This disease refers to thrombophlebitis of the internal jugular vein (IJV), which is the result of bacterial sore throat infection (usually in the form of pharyngitis) that extends into the parapharyngeal space.1–7 However, it can result from other infective foci in the ear, nose, parotid glands, and paranasal sinuses. It is caused by anaerobic oropharyngeal flora with Fusobacterium necrophorum being the usual causative organism. This condition was previously named ‘the forgotten disease’ due to its rarity and because many doctors are unfamiliar with its presence.3,5,6

IJV inflammation may lead to septic emboli that can spread to involve various sites of the body including the lungs, joints, soft tissues, liver, and brain. Previous literature confirmed the involvement of different sites, but the most common presentation is in the lungs, which takes the form of multiple pulmonary shadowing due to septic emboli.4,6,8,9

We describe a case of Lemierre’s syndrome in a 20-year-old Omani female who presented with neurological deficits following a two-week history of upper respiratory tract infection. Our case presents typical findings of this rare condition and a review of the previous literature. Our report emphasizes the importance of a high index of suspicion to reduce the mortality of this disease. To the best of our knowledge, this is the first described case of Lemierre’s syndrome in Oman.

Case Report

A 20-year-old woman with no history of medical illness presented to a primary health care center in Oman with fever, sore throat, and attacks of hemoptysis lasting two weeks. She was diagnosed with upper respiratory tract infection and treated with oral antibiotics. A few days later, she developed weakness of the left upper limb and was referred to Sultan Qaboos University Hospital. She underwent head computed tomography (CT), which revealed a right thalamic lesion suggestive of an abscess. She was then admitted to the hospital. On admission, the patient appeared conscious but ill. She was mildly febrile and had tachypnea and tachycardia. Her oxygen saturation was still maintained. Chest examination showed bilateral crepitation, which was more on the right side. Neurological examinations revealed mild weakness in the left upper limb.

The initial chest radiograph showed multiple nodular infiltrates and small pleural effusion. She was diagnosed with pneumonia with brain abscess.

Initial laboratory tests revealed a white cell count of 21.5 × 109/L (neutrophils 17.9 × 109/L), red blood cell count of 5 × 1012/L, platelet count of 444 × 109/L, C-reactive protein levels of 323 mg/L, and hypochromic microcytic anemia with hemoglobin levels of 10.1 g/dL. Her blood culture was negative.

Figure 1: (a) Axial T1-weighted contrast-enhanced magnetic resonance imaging of the brain showed right thalamic abscess (red arrow). (b) Magnetic resonance angiography showing non-visualization of the transverse sinus, sigmoid sinus, and the internal jugular vein (red arrow).

An echocardiogram was carried out to rule out infective endocarditis, and showed negative results. Brain magnetic resonance imaging (MRI) and magnetic resonance angiography were performed revealing a right thalamic abscess as well as extensive cerebral venous thrombosis involving the left IJV, left straight, and sigmoid and transverse sinuses [Figure 1]. 

Chest CT was performed for further evaluation of the lungs and major vessels in the neck, which revealed multiple bilateral lung consolidations and atelectatic changes and filling defects in the segmental branches of the pulmonary arteries in keeping with pulmonary embolism [Figure 2]. It also showed thrombosis of the left IJV [Figure 3].

Figure 2: (a) Pulmonary angiography with computed tomography of the chest showing a filling defect denoting embolism in the lower lobe segmental branch of the left pulmonary artery (red arrow). (b) The lung fields show multiple atelectatic changes (red arrows) and bilateral pleural effusion.

Figure 3: Contrast-enhanced computed tomography showing a filling defect obstructing the left internal jugular vein denoting thrombosis
(red arrow).

In view of these imaging findings, a diagnosis of Lemierre’s syndrome was made. She was started on intravenous antibiotics (ceftriaxone 2 g twice daily, cloxacillin 2 g every six hours, and clindamycin 600 mg every six hours) and anticoagulation therapy (enoxaparin). Following treatment, the patient showed dramatic clinical improvement with all blood parameters returned to normal. Repeated chest radiographs showed improvement of the pulmonary shadowing. A follow-up brain CT showed a reduction in the size of the abscess. She was then discharged on oral antibiotics. The patient did not make further outpatient visits, although advised.


Lemierre’s syndrome was first described in the 1930s by Andre Lemierre, who studied a series of throat infection cases with cervical extension and septicemia. It was known as ‘the forgotten disease,’ but in the recent years, the number of published cases has increased. The reason for the increase in the number of cases of Lemierre’s syndrome is believed to be the more prudent and judicious antibiotic-prescribing habits in the setting of upper respiratory tract infections, especially pharyngitis, which used to be treated swiftly with penicillin.1,2,10 Some studies have linked the use of non-steroidal anti-inflammatory drugs and steroids, both commonly prescribed to treat pharyngitis, to enhanced bacterial virulence and spread.3 It is most commonly seen in the second and third decades of life (51% and 20%, respectively) with no sex predominance.8 Patients are more vulnerable to this disease during late winter and early spring seasons.9

Fusobacterium species are normal flora of the oral cavity, female genital tract, and gastrointestinal tract. F. nucleatum and F. necrophorum are the most common pathogens causing Lemierre’s syndrome.4 Patients usually present with throat infection followed by local invasion of the lateral pharyngeal space and extension of the disease to the IJV as septic thrombophlebitis.8 Between 63–100% patients develop metastatic infections, commonly to the lungs.5

Radiologists play a crucial role in the diagnosis of IJV thrombosis. Chest X-rays typically demonstrate pulmonary infiltration. Ultrasound is inexpensive and easily available, but it is an operator-dependent investigation. It is commonly used first to diagnose the thrombosed IJV and shows no Doppler flow and incompressible vein.11 CT will subsequently confirm the diagnosis by showing distended thrombosed veins with enhancing walls and intraluminal filling defects.5 MRI is used as a second line of study because it is expensive and not available in all healthcare facilities. It is performed to demonstrate the extension of thrombosis to the brain.4

The treatment of choice of Fusobacterium species in Lemierre’s syndrome is aggressive antibiotics; a combination of intravenous penicillin and metronidazole is most commonly used. Surgical or radiological drainage of pulmonary abscess, mediastinal abscess, or empyema may be recommended if present. The treatment duration is typically 3–6 weeks.3 Anticoagulation therapy has a conflicted role and is only used in 30% of cases. It is combined with antibiotics in patients with extensive and severe thrombosis not responding to antibiotics.12 The mortality rate of this disease is 0–18% and the rate of disseminated intravascular coagulation is 3–9%.5

Review of the previous literature shows that fever, sore throat, neck pain, and neck lymphadenopathy are the most common first presentation of the disease.3–8,11,12 Thrombosis of IJV is detected in Doppler ultrasound of the neck or CT study. Some cases complicated with metastatic infection, mostly to the chest.3,4,6,7,11 Our case of Lemierre’s syndrome presented with similar symptoms of a sore throat with fever and complicated with metastatic infection to the chest and brain. Early suspicion and recognition of the disease by physicians and radiologists is crucial for early management and prevention of further spread of infection.


Lemierre’s syndrome should be suspected in young, healthy patients with prolonged symptoms of pharyngitis. Such patients could develop septicemia, pneumonia, or atypical lateral neck pain. It is a rare disease in the modern era of antimicrobial therapy. The diagnosis is often confirmed by the identification of IJV thrombophlebitis by imaging and growth of anaerobic bacteria F. necrophorum on blood culture. The treatment is prolonged antibiotic therapy combined with anticoagulants.


The authors declared no conflicts of interest.


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